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   Technology and Product Development

    Basic Information

Technology developed: An Optimized Transgene for an Oculargene Therapy (TP19762074638)
Category:
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Jayandharan Giridhara Rao IIT Kanpur Biological Science and Bio Engineering Professor
Vijayata Singh IIT Kanpur Biological Science and Bio Engineering PhD Student
Shamshul Huda IIT Kanpur Biological Science and Bio Engineering PhD Student
G. Narendra Kumar IIT Kanpur Biological Science and Bio Engineering PhD Student
Technical Application Area: Other
If 'Other', please specify:
Biotech Engineering
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: Institution Funding (Self Supported)
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Field Test
Please describe in detail including the TRL Level:
Efforts are made for commercialization

    Abstract:

Applications: The invention shall have use case in gene therapy based products, specially the gene therapy for eye related disorders. Leber congenital amaurosis 2 (LCA2) is an inherited retinal degenerative disorder caused due to mutations in the RPE65 gene, leading to complete blindness Research on gene therapy for LCA2 using adeno-associated virus (AAV) vectors have shown therapeutic response in patients with LCA2 by delivering functional retinal pigment epithelium-65kda protein-encoding gene (RPE65). Strategies to increase the gene transfer potential of AAV2 vectors in the ocular niche are needed for the long-term and increased expression of RPE65 transgene such as strategies like codon optimization of the transgene or the addition of kozak sequence may result in high protein formation.
Advantages: Codon optimized or kozak driven RPE65 vectors will improve efficiency of gene therapy in LCA2 patients.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 0 2022-23
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees? Vipragen Biosciences Private Limited, Laurus labs Ltd., Relianve Life Sciences Pvt. Ltd.
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: J.G. Rao Date of Submission: 10-3-2023



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