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    Basic Information

Technology developed: AMPK inhibition as a novel means to curb cancer metastasis (TP19766149462)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Annapoorni Rangarajan Indian Institute of Science MRDG Professor
Technical Application Area: Other
If 'Other', please specify:
The protein AMP activated Protein Kinase AMPK
Please give more details of new technical application area:
The protein AMP activated Protein Kinase (AMPK) is an energy stress sensor that is activated under conditions that lead to a reduction in energy, such as under hypoxia and nutrient deprivation. Upon activation AMPK acts as a central metabolic regulator to bring about energy homeostatis by inhibiting energy consuming anabolic activities, while activating energy producing catabolic activities. Owing largely to its antigrowth effects, it earned its name as tumor-suppressor. In contrast, our findings identify novel protumorigenic functions of AMPK, particularly in tumor progression leading to metastasis. For eg, we have shown that AMPK is critical for cancer cells to survive matrix detachment, as well as in promoting epithelial-mesenchymal transition (EMT) two key processes that contribute to metastasis (spread of tumor). Thus, we have identified AMPK activation, and thus metabolic alteration, as a key switch that promotes breast cancer progression. Based on our findings, we advocate AMPK inhibition as novel strategy to reduce the burden of metastatis . The major reason for cancer associated deaths. Currently there are no FDA approved AMPK inhibitors available for use in the clinic. Hence, identifying novel AMPK inhibitors, and testing their effect in preventing cancer spread, can have therapeutic application.
Organization(s):
Indian Institute of Science (IISc) Bengaluru
Affiliated Ministry: DBT, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
No
Does the technology have export potential? Yes
Category of Technology developed: Futuristic
Stage of Development: Lab-scale
Please describe in detail including the TRL Level:
NA

    Abstract:

Applications: Attached
Advantages: Currently there are no technologies available to treat cancer metastasis Currently there are no FDA approved AMPK inhibitors Identification of AMPK inhibitors, and their translation into clinic, will be novel

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 3 2014-15

    Commercialization Potential:

Who are the Potential Licensees? Biotech companie
What commercially available products address
the same problem?
Company Product Problem Addressed
None
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Prof KVS Hari Date of Submission: 26-11-2020



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