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   Technology and Product Development

    Basic Information

Technology developed: Apparatus and System for Rapid Diagnosis of Malignant Lesions from Biopsy Tissues for Use Inside the (TP19769865992)
Category: Product(Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Hardik J Pandya Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Assistant Professor
Anil Vishnu G K Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE PhD Scholar
Bhagaban Behera Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE SERB Post-Doctoral Fellow
Arun Baby Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Saeed Rila Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Midhun C Kachapilly Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Annapoorni Rangarajan Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Professor
Technical Application Area: Other
If 'Other', please specify:
Breast cancer diagnosis and Intra operative pre surgical margin assessment
Please give more details of new technical application area:
Description Biomedical devices for rapid diagnosis and screening of cancer is a separate application area of MEMS devices This field incorporates microengineering electronic system design product engineering and software infrastructures to develop robust biomedical systems More specifically in this application area the focus is on developing devices and systems that can aid in the rapid diagnosis of breast lesions during surgery or in the pathology labs to quickly delineate between cancerous and normal tissues to aid in better surgical resection and provide better patient outcomes
Organization(s):
Indian Institute of Science (IISc) Bengaluru
Affiliated Ministry: SERB, DST, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
No
Does the technology have export potential? Yes
Category of Technology developed: Futuristic
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
4

    Abstract:

Applications: 1. A universal solid tissue phenotyping platform based on electro-thermo-mechanical sensing modalities that can be applied for studying a variety of diseases such as breast cancer, colon cancer, oral cancer, pancreatic cancer, to name a few. 2. Delineation between cancer and normal through multi-parametric surface and bulk measurements that take into account the anisotropy of the sample tissue to determine the nature of malignancy of the tissue. 3. Applications involving physical property measurements of live and fixed tissues. 4. Aiding the onco-pathologist’s diagnostic workflow in the pathology lab. 5. A system to aid the surgeon in making a more objective assessment of tumour-normal margin during surgery
Advantages: 1.Existing technology for rapid diagnosis involves frozen section examination and immunohistochemical analysis which both involve elaborate procedures such as sample preparation, staining, microscopy etc. which are time consuming and require skilled manpower. This technology attempts to make this process more automated, objective and requiring lesser amount of skill allowing the surgeon to also perform a rapid assessment before surgery. 2.As an additional label free modality, this technology will help to reduce the rates of false positive and false negative rates in routine immunohistochemical diagnostic procedure for solid tumour cancers. 3.The use of microsensors enables the tool to require only a very small sample to perform the analysis and diagnosis. 4.The construction of the system is in such a manner that it can capture the effects of anisotropy of the sample that could improve the accuracy of diagnosis.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Samsung Tablet 2019-20 85171290
Force sensor 2020-21 90318000
Impedance Analyser 2020-21 903000
Micromanipulator 2017-18 8418990
Arduino Uno and Mega 2018-19 84733030
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
Silicon Wafer 2019-20 38180090
Photoresists 2019-20 37071000
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
FILAMENT PLA 2019-20 39169090
PCB fabricated 2019-20 85177010
Platinum for deposition 2019-20 71101900
Existing R&D Facilities used:
Facilities Year ITC-HS Code
Mask Aligner 2019-20 84862000
Thermal and E Beam Evaporators 2019-20 84198980
3D printer 2019-20 84775900

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 0 2020-21
Publications:
Submitted (No.) Published (No.) Year
0 0 2020-21

    Commercialization Potential:

Who are the Potential Licensees? AIPL
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Prof KVS Hari Date of Submission: 25-11-2020



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