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    Basic Information

Technology developed: Structure, Function and Novel Signaling Pathways of the (TP19763078764)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Prof. Arun K. Shukla Indian Institute of Technology (IIT) Kanpur Biological Sciences & Bioengineering
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: Institution Funding (Self Supported)
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
Ready

    Abstract:

Applications: G Protein Coupled Receptors GPCRs are the main conduit of information transfer across the cell membrane. These receptors and their signaling networks are intricately involved in almost every physiological and pathophysiological process in human body such as cardiovascular regulation, immune response neurotransmission, behavior and mood regulation. About half of the currently prescribed drugs target this class of receptors including alpha and beta blockers, angiotensin receptor blockers and anti-histamines. GPCR targeting drugs are used in congestive heart failure, hypertension asthma allergies schizophrenia Parkinson s disease and cancer. Our goal is to understand the structural basis of activation and signaling of selected noncanonical GPCRs and ultimately, leverage this information to improve therapeutic manipulation in human diseases. We utilize synthetic chaperones generated through combinatorial biology and directed evolution approaches to capture and visualize distinct conformational states of GPCRs and their signaling complexes. Our research projects involve a multifunctional approach including cellular signaling, protein biochemistry, receptor pharmacology and structural biology This figure represents the superimposition of a GPCR G protein complex and a GPCR arresting protein complex. The GPCR component is shown in green and the arresting component is in red. The subunits of the heterotrimeric G proteins are shown in blue G , yellow G and magenta G. This superimposition reflects the overlapping nature of G protein and arresting binding sites in the GPCRs and therefore, explains the arresting mediated G protein signaling termination event of GPCRs
Advantages: G Protein Coupled Receptors GPCRs are the main conduit of information transfer across the cell membrane. These receptors and their signaling networks are intricately involved in almost every physiological and pathophysiological process in human body such as cardiovascular regulation, immune response neurotransmission, behavior and mood regulation. About half of the currently prescribed drugs target this class of receptors including alpha and beta blockers, angiotensin receptor blockers and anti-histamines. GPCR targeting drugs are used in congestive heart failure, hypertension asthma allergies schizophrenia Parkinson s disease and cancer. Our goal is to understand the structural basis of activation and signaling of selected noncanonical GPCRs and ultimately, leverage this information to improve therapeutic manipulation in human diseases. We utilize synthetic chaperones generated through combinatorial biology and directed evolution approaches to capture and visualize distinct conformational states of GPCRs and their signaling complexes. Our research projects involve a multifunctional approach including cellular signaling, protein biochemistry, receptor pharmacology and structural biology This figure represents the superimposition of a GPCR G protein complex and a GPCR arresting protein complex. The GPCR component is shown in green and the arresting component is in red. The subunits of the heterotrimeric G proteins are shown in blue G , yellow G and magenta G. This superimposition reflects the overlapping nature of G protein and arresting binding sites in the GPCRs and therefore, explains the arresting mediated G protein signaling termination event of GPCRs

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Technical Team Date of Submission: 1-5-2023



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