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    Basic Information

Technology developed: Apparatus for High-Throughput Rapid Antibiotic Susceptibility Testing and Methods Thereof (TP19763674190)
Category: Product(Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Hardik J. Pandya Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Assistant Professor
Anil Vishnu G K Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Ph.D. Scholar
Dipshikha Chakravortty Indian Institute of Science, Bengaluru Department of Molecular Reproduction, Biosystems S Professor
Nagasuma Chandra Indian Institute of Science, Bengaluru Department of Biochemistry Professor
Bhagaban Behera Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE SERB Post-Doctoral Fellow
Alekya B Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Ph.D. Scholar
Arun Baby Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Saeed Rila Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Arjun B S Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Ph.D. Scholar
Midhun C Kachapilly Indian Institute of Science, Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Prathik BH Indira Gandhi Institute of Child Health, Bengaluru, Karnataka Neonatologist
Technical Application Area: Other
If 'Other', please specify:
Anti-biotic Susceptibility testing
Please give more details of new technical application area:
Antimicrobial susceptibility testing (AST) is a laboratory procedure performed by medical technologists (clinical laboratory scientists) to identify which antimicrobial regimen is specifically effective for individual patients.
Organization(s):
Indian Institute of Science (IISc) Bengaluru
Indira Gandhi Institute of Child Health, Bengaluru, Karnataka
2020-21
2020-21
2020-21
Affiliated Ministry: SERB, DST, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
No
Does the technology have export potential? Yes
Category of Technology developed: Futuristic
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
4

    Abstract:

Applications: The product is a system for rapid antibiotic susceptibility testing. The system comprises portable electronic platform integrated with a cartridge containing a microfluidic chip, interdigitated electrodes, and microheaters for rapid, real-time, and label-free antibiotic susceptibility testing based on electrical sensing modality. A portable impedance analyser with a port is configured for holding the cartridge containing the microfluidic chip for AST testing. The cartridge can be detached from the platform and the clinical isolate from the patient such as blood, urine, saliva, tear drop, buccal swabs etc. can be loaded onto the cartridge using pipettes, washed using wash buffers, and inserted back to the platform for analysis.
Advantages: The conventional techniques used to determine the minimum inhibitory concentration (MIC) of a drug against the bacteria are time-consuming (24-48 h) and prone to false-negative results. With on-board processing capabilities for performing impedance spectroscopic analysis, data capture, analysis, and visualization the tool can provide results of the test in under 120 minutes. The quantity of clinical isolate required for the testing can be significantly reduced.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Impedance Analyser 2020-21
Micromanipulator 2017-18
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
Silicon Wafer 2019-20 38180090
Photoresists 2019-20 37071000
Glass Wafer 2019-20 38180090
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
FILAMENT PLA 2019-20 39169090
PCB fabricated 2019-20 85177010
Gold for deposition 2019-20 71081200
Raspberry Pi 2019-20 84715000
Existing R&D Facilities used:
Facilities Year ITC-HS Code
3D printer 2019-20 84775900
Wet Dry Etching 2020-21 84799090
Wirebonder 2020-21 85176990
Universal Testing Machine 2020-21 84864000
Mask Alighner 2020-21 84862000
Thermal and E-Beam Evaporators 2020-21 84198980

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 0 2020-21
Publications:
Submitted (No.) Published (No.) Year
0 1 2019-20

    Commercialization Potential:

Who are the Potential Licensees? Nil
What commercially available products address
the same problem?
Company Product Problem Addressed
Thermo Scientific Sensititre Manual, Long analysis time
Merlin MICRONAUT Manual, Long analysis time
Synbiosis mASTer Manual, Long analysis time
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Prof KVS Hari Date of Submission: 25-11-2020



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