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    Basic Information

Technology developed: Structural basis of the Human Complement Anaphylatoxin C5a Interaction with its Cognate G Protein-Coupled Receptor, the C5aR (TP19765654262)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Prof. Arun Shukla Indian Institute of Technology (IIT) Kanpur Biological Sciences And Bioengineering
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: Institution Funding (Self Supported)
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
Ready

    Abstract:

Applications: The complement system is a critical part of body s defense mechanism against pathological infections. One of the most potent inflammatory peptides of the complement system the C5a exerts its effect by binding to and activating a G Protein Coupled Receptor the C5aR. The interaction of C5a and C5aR and downstream signaling is critical for rapid response to pathogenic infections. Here we propose to crystallize and determine the crystal structure of C5a C5aR complex to reveal the structural basis C5a C5aR interaction. This novel information should improve our understanding of C5a C5aR signaling system and provide a structural framework to facilitate novel drug discovery and design for sepsis and inflammation.
Advantages: The complement system is a critical part of body s defense mechanism against pathological infections. One of the most potent inflammatory peptides of the complement system the C5a exerts its effect by binding to and activating a G Protein Coupled Receptor the C5aR. The interaction of C5a and C5aR and downstream signaling is critical for rapid response to pathogenic infections. Here we propose to crystallize and determine the crystal structure of C5a C5aR complex to reveal the structural basis C5a C5aR interaction. This novel information should improve our understanding of C5a C5aR signaling system and provide a structural framework to facilitate novel drug discovery and design for sepsis and inflammation.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Technical Team Date of Submission: 1-5-2023



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