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   Technology and Product Development

    Basic Information

Technology developed: Recombinant NS1 Protein Based Indirect IgG ELISA for Sero Japanese encephalitis IgM ELISA kit for sw (TP19766037153)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Himani Dhanze ICAR-IVRI, Izatnagar Veterinary Public Health Scientist
M. Suman Kumar ICAR-IVRI, Izatnagar
K.N. Bhilegaonkar ICAR-IVRI, Izatnagar
Ashok Kumar Division of Animal Science, Krishi Bhavan, ICAR
B.P. Mishra ICAR-IVRI, Izatnagar
R.K. Singh ICAR-IVRI, Izatnagar
Technical Application Area: Healthcare
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
ICAR Indian Veterinary Research Institute (IVRI) Izatnagar Bareilly
Affiliated Ministry: Institution Funding (Self Supported)
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Commercialized
Please describe in detail including the TRL Level:
Technology assigned to Agrinnovate India Ltd., New Delhi for technology transfer or commercialization.

    Abstract:

Applications: Japanese encephalitis virus JEV is one of the major causes of encephalitis in children and it is estimated that annually JEV causes 50000 to 67900 cases leading to 10000 to 20000 deaths globally.Swine, being an amplifier host of JEV, plays an important role in its epidemiology. Early detection of IgM antibodies against JEV in swine is a feasible alternative for initiating necessary measures to prevent the spread of infection to humans. Moreover, none of the JE IgM ELISA kits for swine are manufactured indigenously and the high cost of the imported kits is a huge economical burden, especially for developing countries
Advantages: It does not involve handling of live JE virus, Excellent repeatability as revealed by intra and inter institutional laboratory validation studies, Appreciable relative diagnostic sensitivity 95.34 percent and specificity 98.6 percent, Hitherto, more than 3000 field swine serum samples tested using this kit,Cost effective as compared to existing commercial kits.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
1 0 2019-20

    Commercialization Potential:

Who are the Potential Licensees? All the companies who are involved in manufacturing diagnostics for human and animal diseases.
What commercially available products address
the same problem?
Company Product Problem Addressed
1. Bluegene, China Porcine Japanese encephalitis IgM antibody JE IgM ELISA kit Our kit is compartively cheaper than the imported kit
Would you like to develop this invention further with
corporate research support?
No
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: The Director Date of Submission: 25-8-2020



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