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   Technology and Product Development

    Basic Information

Technology developed: Repurposing of FDA approved drugs against SARS-CoV-2 (TP19769066002)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Tanweer Hussain Indian Institute of Science, Bengaluru Molecular Reproduction, Development and Genetics Assistant Professor
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
We are screening FDA approved drugs against Non-structural protein 1 (Nsp1) of SARS-CoV-2. By binding to the 40S ribosomal subunit of host cells, Nsp1 renders it translationally inactive. Nsp1 helps the virus in evading the host immune system by suppressing the production of interferons thereby affecting the entire host anti-viral response. Hence Nsp1 is an attractive antiviral target.
Organization(s):
Indian Institute of Science (IISc) Bengaluru
Affiliated Ministry: Select One...
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Does the technology have export potential? 1
Category of Technology developed: Futuristic
Stage of Development: Lab-scale
Please describe in detail including the TRL Level:
2

    Abstract:

Applications: The C-terminal helices of Nsp1 binds in the mRNA channel of the 40S and hence blocks protein synthesis in the host. This helps the virus to escape the host immune system as the production of interferons is suppressed. Hence, the anti-viral response by the host is blocked. Therefore, the combinational approach to figure out if any currently available FDA approved drugs can bind to the C-terminal helices of Nsp1 and hence that would prevent binding to 40S. Thus, such drugs can be repurposed for Covid-19.
Advantages: The drugs that would be shortlisted in this study will be FDA approved, hence, such drugs can be immediately repurposed for Covid-19.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Prof KVS Hari Date of Submission: 25-11-2020



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