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    Basic Information

Technology developed: Molecular and Biochemical Characterization of Sachharomyces Cerevisiae Actin Related Proctein 8 (TP19769623234)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Prof. Saravanan Matheshwaran Indian Institute of Technology (IIT) Kanpur Biological Sciences and Bioengineering
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: Institution Funding (Self Supported)
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
Ready

    Abstract:

Applications: The eukaryotic genome is packaged into nucleosomes, in which the DNA is wrapped around histone octamers and forms higher order chromatin. Alteration of chromatin structure is essential for DNA transaction processes like replication, transcription, recombination and repair. It has been shown that Actin Related Proteins ARPs are part of INO80 chromatin remodeling complex, the only known complex have role in DNA damage recognition and repair. Several studies have demonstrated that access to the DNA damage buried in nucleosome core is essential to repair the DNA damage. Recent studies have shown that Arp8 can binds to core histone and hypothesized that it may have role in nucleosome assembly and disassembly during and after the repair. However it is not clear, how these complexes have such role and what is the molecular function for Arp8. The project will help us to understand the molecular and biochemical function of Arp8 on its own or with other interacting proteins.
Advantages: The eukaryotic genome is packaged into nucleosomes, in which the DNA is wrapped around histone octamers and forms higher order chromatin. Alteration of chromatin structure is essential for DNA transaction processes like replication, transcription, recombination and repair. It has been shown that Actin Related Proteins ARPs are part of INO80 chromatin remodeling complex, the only known complex have role in DNA damage recognition and repair. Several studies have demonstrated that access to the DNA damage buried in nucleosome core is essential to repair the DNA damage. Recent studies have shown that Arp8 can binds to core histone and hypothesized that it may have role in nucleosome assembly and disassembly during and after the repair. However it is not clear, how these complexes have such role and what is the molecular function for Arp8. The project will help us to understand the molecular and biochemical function of Arp8 on its own or with other interacting proteins.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Technical Team Date of Submission: 1-5-2023



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